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Cycloguanil hydrochloride

CAS No. 152-53-4

Cycloguanil hydrochloride ( Chloroguanide Triazine )

Catalog No. M20150 CAS No. 152-53-4

Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cycloguanil hydrochloride
  • Note
    Research use only not for human use.
  • Brief Description
    Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).
  • Description
    Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms respectively).
  • Synonyms
    Chloroguanide Triazine
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    152-53-4
  • Formula Weight
    288.18
  • Molecular Formula
    C11H14ClN5.ClH
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL (69.4 mM);Water: 5 mg/mL (17.35 mM)
  • SMILES
    Cl.CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wright JD et al. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4.
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